Bench2Bedside:
What is the central problem Adhere+ is solving in today’s healthcare environment?

Jim Breidenstein:
Adhere+ addresses the gap between what happens in the clinic and what happens at home. Millions of patients leave their appointments with clear instructions about medication, lifestyle changes, or physical therapy. But most providers can’t monitor in real-time whether those plans are followed. That disconnect is especially problematic in chronic care settings like pain management, psychiatry, and neurology, where nonadherence can lead to worsening symptoms, ER visits, or avoidable complications. Adhere+ gives clinicians a meaningful path to maintain and build upon that connection, and most importantly, it does so asynchronously. That means patients can engage with their care plan on their own time, in ways that fit naturally into their daily routines. For providers, it enables scalable oversight without adding time-consuming tasks or disrupting existing workflows. It’s a model that respects both the patient’s life and the clinician’s bandwidth.

Bench2Bedside:
How does the Adhere+ platform work in practice?

Dan Cohen:
The platform is structured to develop patient reported outcomes via the use of the AMA CPT-supported protocols in RTM. RTM allows providers to track clinical data between scheduled patient visits. It tracks various direct and indirect data including pain scores, medication use, mood fluctuations, work attendance, sleep/fatigue and even functional status. Patients respond to brief, targeted assessments through mobile devices, which are customized to the care plan. The data are synthesized and presented back to the care team in real time. The power of this is twofold: providers can intervene early if something’s going off-track, and patients feel more engaged because they’re in an ongoing dialogue with their care team.

Bench2Bedside:
One of the concerns with digital tools is that they often place extra burden on providers. How does Adhere+ avoid that?

Dan Cohen:
That’s why we designed Adhere+ with integration and simplicity in mind. Our system plugs into existing EHR environments and adapts to each provider’s clinical workflow. More importantly, it doesn’t require patients or staff to install complicated apps or learn new systems. The asynchronous nature of RTM means clinicians can review patient data on their own time, without needing to schedule additional video visits or phone calls. We also support clinical documentation and coding for RTM CPT codes, so the value is measurable from day one.

Bench2Bedside:
What sets Adhere+ apart from traditional telehealth platforms?

Jim Breidenstein:
The Adhere+ Platform is a telehealth approach that optimizes patient care. As opposed to telemedicine which requires that the provider log in at the same time as the patient, telehealth is an asynchronous model that is designed to be scalable for long-term chronic care. RTM, and specifically the Adhere+ approach, is about behavioral and functional data. It captures how patients are doing day-to-day, and it does it through HIPAA compliant tools similar to what they already use, like SMS or email. That’s what makes it so powerful for improving adherence: it’s passive, low-friction, and evidence-based.

Bench2Bedside:
What types of practices are gaining the most value from Adhere+ so far?

Jim Breidenstein:
We’re seeing strong adoption among medication-based and interventional pain specialists, behavioral health providers, neurology practices, and across other specialties where long-term patient management is essential. These clinicians are often under pressure to manage or reduce opioid use, prevent unnecessary interventions, and demonstrate improved outcomes. Adhere+ helps them do that. Our partners are using the platform not just to identify problems early, but to guide treatment adjustments, support value-based care models, and strengthen documentation for audit and compliance purposes.

Bench2Bedside:
One of the promises of Remote Therapeutic Monitoring is its ability to improve patient-provider communication outside of visits. How does that translate into better care and stronger outcomes?

Dan Cohen:
The most powerful aspects of RTM are its ability to document, in real time, what’s happening between visits. This isn’t just about protecting providers from liability. It’s about enabling timely, informed actions to avoid adverse events and optimize treatment interventions. Patients often assume their provider knows if they’re struggling with a regimen, but without RTM, that feedback loop is broken. When patients receive consistent, personal guidance from their physician and know they, too, are a key component of their treatment, it builds trust. One patient told us she felt like her doctor was “right there with her” because of the messages she received. That connection increases adherence, which in turn leads to better outcomes.

Bench2Bedside:
Looking ahead, what are the next frontiers for Adhere+?

Jim Breidenstein:
Our roadmap includes deeper integration with EHRs, expanded support for value-based contracts, and new features that surface insights more proactively through AI and machine learning. Ultimately, we believe adherence isn’t just about compliance, it’s about empowering people to engage in their care. That’s the mission we’re driving toward.